Rosemary extract: carnosic acid
Rosemary leaf (Rosmarinus officinalis) is where GNM-X gets carnosic acid, the best-studied Nrf2 activator in any culinary herb. It binds KEAP1, the protein that holds Nrf2 back, at the exact cysteines that control it, so Nrf2 is released and the cell raises its glutathione (Satoh et al., 2008, PMID 17995931). In that work carnosic acid also reached the brain and protected neurons from oxidative stress.
Taken by mouth, rosemary extract at 500 mg a day improved markers of oxidative stress in adult women, with liver and kidney values unchanged (Tremêa et al., 2024, PMID 39135397), and a month of oral rosemary improved memory, anxiety and sleep quality in university students against placebo (Nematolahi et al., 2018, PMID 29389474). Looking for a carnosic acid supplement? GNM-X delivers it with two more Nrf2 activators in the same capsule.
Ginger extract: 6-shogaol
Ginger root (Zingiber officinale) brings 6-shogaol, the compound that gives dried ginger its bite. It switched on the Nrf2-ARE pathway in human skin cells and raised Nrf2, NQO1 and HO-1 (Yang et al., 2020, PMID 32429495); a ginger extract rich in 6-shogaol did the same in liver cells and restored the liver's antioxidant enzymes (Bak et al., 2012, PMID 22763741).
In people, ginger supplements lowered CRP and TNF-α across 16 randomized trials with 1,010 participants (Morvaridzadeh et al., 2020, PMID 32763761) and raised glutathione peroxidase and total antioxidant capacity across 12 more (PMID 33458848).
Sophora japonica: luteolin
The flower bud of Sophora japonica is GNM-X's source of luteolin, a flavonoid. Luteolin switched on Nrf2 and four of the enzymes it controls (HO-1, NQO1, GCLC and SOD1) and cut oxidative damage in the liver (Rajput et al., 2021, PMID 34439516). It also calms inflammation through NF-κB, the other switch of the cell's stress response (Aziz et al., 2018, PMID 29801717).
The United States Pharmacopeia's safety review of Sophora flower and bud found no serious adverse events in clinical or animal studies (Madden et al., 2022, PMID 35307893). If you were shopping for a luteolin supplement or a Sophora japonica extract, it is already in GNM-X.
Niacin (vitamin B3)
The US label adds 7 mg of niacin (as niacinamide), 44% of the Daily Value. Niacin is the vitamin your cells turn into NAD, the coenzyme of energy production (Kennedy, 2016, PMID 26828517). It is a nutritional amount, well inside the everyday range.
Why the three work together
Each extract releases Nrf2 in its own way, and the three were also studied as one combination: rosemary, ginger and luteolin in a 10:5:1 ratio activated Nrf2 in human liver cells, raised the protective genes and strengthened the cells against oxidative stress (Hybertson et al., 2022, PMID 35252766). The formula is Nrf2.0® technology from Pathways Bioscience, the company co-founded by Joe McCord, who co-discovered superoxide dismutase, and licensed to Activz.
New to Nrf2? What Nrf2 is and how it is switched on. Comparing labels? GNM-X vs Protandim, ingredient by ingredient.
The full US label
Supplement Facts · serving size 1 capsule · 30 servings per bottle.
| Ingredient | Amount | % DV |
|---|---|---|
| Niacin (as niacinamide) | 7 mg NE | 44% |
| Proprietary blend: rosemary leaf extract (Rosmarinus officinalis), ginger root extract (Zingiber officinale), Sophora japonica bud luteolin | 91 mg | † |
† Daily Value not established.
- Other ingredients: microcrystalline cellulose (silicified), colloidal silicon dioxide, stearic acid, dicalcium phosphate dihydrate. They fill the capsule and keep the dose even.
- Calories: about 1 kcal per capsule.
- Caffeine, gluten, lactose: none on the ingredient list.
- How to take it: 1 capsule a day. A bottle is a month.
- If you are pregnant, nursing or take a blood thinner, check with your doctor first.
Leer los ingredientes en español
GNM-X prices in the US
One capsule a day, 30 capsules a bottle: each bottle is a month. Free USPS shipping in 2–5 business days, and no subscription.